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Water → HCID 21473343, 화합물

HRID 2293979
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인쇄 미리보기

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HRID 2293979 반응식
F[C:2]1[C:24]([O:25][CH:26]([F:28])[F:27])=[C:23]([F:29])[C:22]([F:30])=[CH:21][C:3]=1[C:4]([C:6](=[CH:12][NH:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C(=O)([O-])O.[Na+].O>CN(C)C=O>[F:30][C:22]1[CH:21]=[C:3]2[C:2](=[C:24]([O:25][CH:26]([F:28])[F:27])[C:23]=1[F:29])[N:13]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)[CH:12]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:4]2=[O:5]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 178471985HCID 178471985, 화합물

생성물 1

HCID 21473343HCID 21473343, 화합물수율 48.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

In 50 ml of N,N-dimethylformamide was dissolved 5.6 g (0.013 mole) of ethyl 2-(2,4,5-trifluoro-3-difluoromethoxybenzoyl)-3-(2-pyridylmethylamino)acrylate, and 2.2 g (0.026 mole) of sodium hydrogen carbonate was added thereto. The mixture was stirred at 120° C. for 30 minutes. Then, the reaction mixture was poured into 200 ml of water, and crystals precipitated were collected by filtration. The collected crystals were washed with water and ethanol and dried to obtain 2.6 g of ethyl 6,7-difluoro-8-difluoromethoxy-1-(2-pyridylmethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate as yellow crystals.

후처리

  1. additionwas added
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. washThe collected crystals were washed with water and ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-6a899a84ec7b409b9791547b9eb7e101
출처 데이터셋
uspto-grants-1997_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05688791

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