Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Hydroxy-4-phenylaminopyrrolidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine | HCID 21473347 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Hydroxy-4-phenylaminopyrrolidine hydrochloride | HCID 21473349 | — |
반응 단계
In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05688791 |
| 출처 데이터셋 | uspto-grants-1997_11 |
| ORD ID | ord-00670e6f07064619996405877f3459db |
| 출처 메모 | uspto-grants-1997_11 |