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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2294009생성일: 2026년 10월 25일

Hydrochloric Acid → 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride

https://huagongshe.com/reaction/2294009

반응식

참여 물질

역할이름HCID투입량
반응물Hydrochloric AcidHCID 313—
반응물2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamineHCID 9862339—
용매EthanolHCID 702—
생성물2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochlorideHCID 2147371194.4%

반응 단계

A solution of 0.177 g (0.00053 mol) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl )-pyrimidin-4-ylamine in 20 ml of ethanol was treated with 0.15 ml (0.000525 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.10 g (47%) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 212°-214°.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05688798
출처 데이터셋uspto-grants-1997_11
ORD IDord-aa119e3e72dc4c73b0141cc73f0aba92
출처 메모uspto-grants-1997_11