Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine | HCID 21473633 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride | HCID 21473632 | 77% |
반응 단계
0.23 g (0.00077 mol) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 220 ml of hot methanol. The solution was treated at room temperature with 0.44 ml (0.00154 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.22 g (77%) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as whited crystals; m.p. 220°-222°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05688798 |
| 출처 데이터셋 | uspto-grants-1997_11 |
| ORD ID | ord-60f3192f14224afc936563c5caeac9ae |
| 출처 메모 | uspto-grants-1997_11 |