Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 5-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine | HCID 21473619 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride | HCID 21473618 | 105.4% |
반응 단계
0.23 g (0.00073 mol) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine was dissolved in 250 ml of hot methanol. The solution was treated at room temperature with 0.84 ml (0.00293 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from methanol/diethyl ether. 0.27 g (96%) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride (1:2.3) was obtained as white crystals; m.p. 215°-216°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05688798 |
| 출처 데이터셋 | uspto-grants-1997_11 |
| ORD ID | ord-c7d476bda2394c02a6f3f9a7f7daf958 |
| 출처 메모 | uspto-grants-1997_11 |