Hydrochloric Acid → 5-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride

HRID 2294039

반응식

HRID 2294039 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[C:17]([NH2:23])=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[ClH:24]>CO>[ClH:24].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[C:17]([NH2:23])=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 214736195-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine

생성물 1

HCID 214736185-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride수율 105.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.23 g (0.00073 mol) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine was dissolved in 250 ml of hot methanol. The solution was treated at room temperature with 0.84 ml (0.00293 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from methanol/diethyl ether. 0.27 g (96%) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride (1:2.3) was obtained as white crystals; m.p. 215°-216°.

후처리

  1. customrecrystallized from methanol/diethyl ether

출처 및 근거

ORD 기록
ord-c7d476bda2394c02a6f3f9a7f7daf958
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688798

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