Ammonia → HCID 21474075, 화합물

HRID 2294192노트

반응식

HRID 2294192 반응식
[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([Br:15])=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH3:16]>CO>[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([Br:15])=[CH:8][C:3]=1[C:4]([NH2:16])=[O:5]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 21474098HCID 21474098, 화합물

생성물 1

HCID 21474075HCID 21474075, 화합물수율 75%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

25.8 g (93.8 mmol) of methyl 2-amino-5-bromo-4-nitro-benzoate were dissolved in 800 ml of methanol and saturated with ammonia at -40° C. Subsequently, the mixture was stirred at room temperature overnight. The solution was concentrated and the residue was triturated with methylene chloride. The precipitate was filtered off under suction and dried. 18.3 g (75%) of 2-amino-5-bromo-4-nitro-benzamide were obtained as orange coloured crystals;

후처리

  1. concentrationThe solution was concentrated
  2. customthe residue was triturated with methylene chloride
  3. filtrationThe precipitate was filtered off under suction
  4. customdried

출처 및 근거

ORD 기록
ord-9b69b947b99b4ce18f1093ce412613ad
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688803

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