1-Azido-3-(benzyloxy)propan-2-ol → 1-Amino-3-(benzyloxy)propan-2-ol

HRID 2294317노트

반응식

HRID 2294317 반응식
[CH2:1]([O:8][CH2:9][CH:10]([OH:15])[CH2:11][N:12]=[N+]=[N-])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([O:8][CH2:9][CH:10]([OH:15])[CH2:11][NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 132105261-Azido-3-(benzyloxy)propan-2-olHCID 21226445Aluminium lithium hydride

생성물 1

HCID 3427951-Amino-3-(benzyloxy)propan-2-ol수율 70.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A procedure similar to that described in Preparation 13 was repeated, except that 5.7 g of 3-benzyloxy-2-hydroxypropylazide (prepared as described in Preparation 47), 2.09 g of lithium aluminum hydride and 250 ml of anhydrous tetrahydrofuran were used, to give 3.5 g of the title compound as white crystals, melting at 72° C. to 74° C.

후처리

  1. customA procedure similar to that described in Preparation 13

출처 및 근거

ORD 기록
ord-23f8285c55874e8aa5e6758bd909de12
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688823

반응 노트

불러오는 중…