Methanol → 3-Phenylthio-2-hydroxypropylazide

HRID 2294349노트

반응식

HRID 2294349 반응식
[C:1]1([S:7][CH2:8][CH:9]2[CH2:11][O:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N-:12]=[N+:13]=[N-:14].[Na+].C(OC)=O.CO>O>[C:1]1([S:7][CH2:8][CH:9]([OH:10])[CH2:11][N:12]=[N+:13]=[N-:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 7865Methyl formateHCID 33557Sodium AzideHCID 110949982-((Phenylsulfanyl)methyl)oxirane

생성물 1

HCID 214747633-Phenylthio-2-hydroxypropylazide수율 91.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A procedure similar to that described in Preparation 12 was repeated, except that 7.2 g of phenylthiomethyloxirane (prepared as described in Preparation 85), 14 g of sodium azide, 65 ml of methyl formate and 270 ml of an 8:1 by volume mixture of methanol and water were used, to give 8.33 g of the title compound as a colorless oil having an Rf value of 0.23 (on silica gel thin layer chromatography, using a 1:10 by volume mixture of ethyl acetate and hexane as the developing solvent).

후처리

  1. customA procedure similar to that described in Preparation 12

출처 및 근거

ORD 기록
ord-12e8e3cc091e494b885bd119f6b80311
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688823

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