Aluminium lithium hydride → 1-Amino-2-phenylthio-2-propanol

HRID 2294350노트

반응식

HRID 2294350 반응식
[C:1]1([S:7][CH2:8][CH:9]([OH:14])[CH2:10][N:11]=[N+]=[N-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([S:7][CH2:8][CH:9]([OH:14])[CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 214747633-Phenylthio-2-hydroxypropylazide

생성물 1

HCID 1137321-Amino-2-phenylthio-2-propanol수율 97.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A procedure similar to that described in Preparation 13 was repeated, except that 8 g of 3-phenylthio-2-hydroxypropylazide (prepared as described in Preparation 86), 2.9 g of lithium aluminum hydride and 400 ml of anhydrous tetrahydrofuran were used, to give 6.8 g of the title compound, melting at 57° C. to 61° C.

후처리

  1. customA procedure similar to that described in Preparation 13

출처 및 근거

ORD 기록
ord-a717dde961aa44408930c5ebcd1f2681
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688823

반응 노트

불러오는 중…