참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 반응물 | Diethyl 5-iodo-2-furanphosphonate | HCID 22280644 | — |
| 촉매 | Bis(acetonitrile)dichloropalladium | HCID 6093782 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Diethyl 5-(4-fluorophenyl)-2-furanphosphonate | HCID 22349233 | — |
반응 단계
A mixture of diethyl 5-iodo-2-furanphosphonate (1 mmol), 4-fluorophenylboronic acid (2 mmol), diisopropylethylamine (DIEA) (4 mmol) and bis(acetonitrile)dichloropalladium(II) (0.05 mmol) in 6 mL DMF was heated at 75° C. for 16 h. Extraction and chromatography provided diethyl 5-(4-fluorophenyl)-2-furanphosphonate as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07563774B2 |
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| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-d5049d1cc90a43e491ff842861e10a18 |
|---|
| 출처 메모 | uspto-grants-2009_07 |
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