Diisopropylethylamine → Diethyl 5-(4-fluorophenyl)-2-furanphosphonate

HRID 229439

반응식

HRID 229439 반응식
I[C:2]1[O:6][C:5]([P:7]([O:12][CH2:13][CH3:14])(=[O:11])[O:8][CH2:9][CH3:10])=[CH:4][CH:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1.C(N(C(C)C)CC)(C)C>CN(C=O)C.CC#N.CC#N.Cl[Pd]Cl>[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[O:6][C:5]([P:7]([O:12][CH2:13][CH3:14])(=[O:11])[O:8][CH2:9][CH3:10])=[CH:4][CH:3]=2)=[CH:18][CH:17]=1

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 2856454-Fluorophenylboronic acidHCID 22280644Diethyl 5-iodo-2-furanphosphonate

생성물 1

HCID 22349233Diethyl 5-(4-fluorophenyl)-2-furanphosphonate

시약·촉매·용매 2

HCID 6093782Bis(acetonitrile)dichloropalladium촉매HCID 6228Dimethylformamide용매

반응 조건

온도
75 °C

실험 절차

A mixture of diethyl 5-iodo-2-furanphosphonate (1 mmol), 4-fluorophenylboronic acid (2 mmol), diisopropylethylamine (DIEA) (4 mmol) and bis(acetonitrile)dichloropalladium(II) (0.05 mmol) in 6 mL DMF was heated at 75° C. for 16 h. Extraction and chromatography provided diethyl 5-(4-fluorophenyl)-2-furanphosphonate as an oil.

후처리

  1. extractionExtraction and chromatography

출처 및 근거

ORD 기록
ord-d5049d1cc90a43e491ff842861e10a18
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07563774B2

연결된 노트

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