Ethylene Glycol → Polyethylene glycol monolaurate

HRID 2294760

반응식

HRID 2294760 반응식
[CH2:1]([OH:4])[CH2:2][OH:3].CC(C)=O.[C:9](Cl)(=[O:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>N1C=CC=CC=1>[OH:3][CH2:2][CH2:1][O:4][C:9](=[O:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 174Ethylene GlycolHCID 180AcetoneHCID 8166Dodecanoyl chloride

생성물 1

HCID 62699Polyethylene glycol monolaurate수율 95.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Under cooling with ice, ethylene glycol (434 mg) was dissolved into acetone (20 ml), and pyridine (632 mg) was added thereto and then lauroyl chloride (1532 mg) was added dropwise thereto. The temperature of the solution was warmed to room temperature, and it was stirred for 2 hours. The mixture was evaporated. To the residue was added water, and the solution was extracted with ethyl acetate. The organic layer was washed with water (three times), dried over magnesium sulfate and evaporated. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1) to give the title compound (1.63 g) having the following physical data.

후처리

  1. additionwas added
  2. customThe mixture was evaporated
  3. additionTo the residue was added water
  4. extractionthe solution was extracted with ethyl acetate
  5. washThe organic layer was washed with water (three times)
  6. dry with materialdried over magnesium sulfate
  7. customevaporated
  8. customThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1)

출처 및 근거

ORD 기록
ord-7d11efc8ffa84e98977b6dbc75123864
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05690957

연결된 노트

불러오는 중…