Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Methylamino)benzoic acid → Cis-4-(methylamino)cyclohexanecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Methylamino)benzoic acid | HCID 66345 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Rhodium | HCID 23948 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Cis-4-(methylamino)cyclohexanecarboxylic acid | HCID 429561 | 75% |
반응 단계
A slurry of 33.0 g (0.218 m) of 4-(methylamino)benzoic acid and 4.0 g of 5% rhodium on alumina catalyst in 350 ml of water was shaken under 1500 psig of hydrogen for 24 hours. The insolubles were removed by filtration. The slurry from partial removal of water under reduced pressure was diluted with 300 ml of N,N-dimethylformamide and chilled. The precipitated solid was filtered, washed with several portions of cold acetone, and dried to yield 23 g (75%) of 4-(methylamino)cyclohexanecarboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04424213 |
| 출처 데이터셋 | uspto-grants-1984_01 |
| ORD ID | ord-58d2685837484985a77bef64d1f51f42 |
| 출처 메모 | uspto-grants-1984_01 |