Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-4-nitrobenzonitrile → 4-Amino-2-chlorobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-4-nitrobenzonitrile | HCID 141401 | — |
| 용매 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 생성물 | 4-Amino-2-chlorobenzonitrile | HCID 88728 | 598.3% |
반응 단계
A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began. Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts. Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water. The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78%, mp 117° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04424371 |
| 출처 데이터셋 | uspto-grants-1984_01 |
| ORD ID | ord-00dd216749eb4b8bb83edd99435101ce |
| 출처 메모 | uspto-grants-1984_01 |