Bupropion → Bupropion toluene

HRID 229561

반응식

HRID 229561 반응식
ClCC[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.BrBr.C(N)(C)(C)C.[CH3:19][CH:20]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:21]([C:23]1[CH:24]=[CH:25][CH:26]=[C:27]([Cl:29])[CH:28]=1)=[O:22]>C(Cl)Cl>[CH3:19][CH:20]([NH:30][C:31]([CH3:32])([CH3:34])[CH3:33])[C:21]([C:23]1[CH:24]=[CH:25][CH:26]=[C:27]([Cl:29])[CH:28]=1)=[O:22].[C:6]1([CH3:4])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

6

반응물 4

HCID 444BupropionHCID 6385Tert-ButylamineHCID 24408BromineHCID 702953-Chloropropiophenone

생성물 1

HCID 66960545Bupropion toluene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Chloro-propiophenone starting material was brominated in methylene chloride by dropping bromine under controlled conditions. On reaction completion the mother liquor was worked up and then the second reaction was executed by transferring the bromoderivative solution onto the tert-butylamine. The second substitution reaction (the tert-butylamine amino-group substitutes the bromine atom) forms the final bupropion molecule. After work up of the mother liquor, a bupropion toluene solution was obtained. The solvent was evaporated and bupropion was dissolved in isopropanol. From the isopropanol solution, the hydrobromide was precipitated with hydrogen bromide gas. On precipitation completion, the product was centrifuged, washed with isopropanol and dried under vacuum. On dryer discharge approval it was discharged in Kraft drums within double polyethylene bags.

후처리

  1. customOn reaction completion the mother liquor
  2. customthe second reaction

출처 및 근거

ORD 기록
ord-605f58bacf674a288929e4698d912980
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07563823B2

연결된 노트

불러오는 중…