Tetrahydrofuran → HCID 53718407, 화합물

HRID 2295735노트

반응식

HRID 2295735 반응식
O1CCCC1.Cl.[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:9]=1.[CH3:28][C:29](=[CH:33][CH3:34])[C:30](Cl)=[O:31]>C(N(CC)CC)C>[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][N:25]([C:30](=[O:31])[C:29]([CH3:28])=[CH:33][CH3:34])[CH2:24][CH2:23]2)[N:9]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 30157932-Methylbut-2-enoyl chlorideHCID 204738332-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride

생성물 1

HCID 53718407HCID 53718407, 화합물수율 47.4%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To 20 ml of tetrahydrofuran were added 2.4 g of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride and 2.6 g of triethylamine, after which the mixture was stirred for 20 minutes. There was then added 0.7 g of 2,3-dimethylacryloyl chloride, after which the mixture was stirred at room temperature for 12 hours. The crystals which were produced were collected by filtration, washed with water and recrystallized from ethanol, to give 1.04 g of the desired Compound No. 3 in the form of pale yellow prisms melting at 219.5°-221.5° C.

후처리

  1. stirringafter which the mixture was stirred at room temperature for 12 hours
  2. customThe crystals which were produced
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-69487d0f1ece4a14be25c892c599fac4
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04426382

반응 노트

불러오는 중…