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Tetrahydrofuran → 4-Amino-6,7-dimethoxy-2-[4-(2-pentenoyl)-1-piperazinyl]-quinazoline

HRID 2295737
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HRID 2295737 반응식
O1CCCC1.Cl.[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:9]=1.[C:28](Cl)(=[O:33])[CH:29]=[CH:30][CH2:31][CH3:32]>C(N(CC)CC)C>[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][N:25]([C:28](=[O:33])[CH:29]=[CH:30][CH2:31][CH3:32])[CH2:24][CH2:23]2)[N:9]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 2760310HCID 2760310, 화합물HCID 204738332-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride

생성물 1

HCID 545194944-Amino-6,7-dimethoxy-2-[4-(2-pentenoyl)-1-piperazinyl]-quinazoline수율 50.3%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To 20 ml of tetrahydrofuran were added 2.4 g of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride and 2.6 of triethylamine, after which the mixture was stirred for 20 minutes. There was then added 0.78 g of 2-pentenoyl chloride, after which the mixture was stirred at room temperature for 15 hours. The resulting crystals were collected by filtration, washed with water and recrystallized from ethanol, to give 1.23 g of the desired Compound No. 5 in the form of pale brown needles melting at 246°-247° C.

후처리

  1. stirringafter which the mixture was stirred at room temperature for 15 hours
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with water
  4. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-6d7ef498ce714f46b4899d87fa3e9678
출처 데이터셋
uspto-grants-1984_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04426382

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