참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 4-Isopropylbenzyl chloride | HCID 74916 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Isopropylphenylacetonitrile | HCID 138222 | 102.2% |
반응 단계
To a stirred solution of 100 g of 4-isopropylbenzyl chloride in 1500 mL of N,N-dimethylformamide was added 32.0 g of sodium cyanide under ice-cooling. The mixture was stirred at 70° C. for 4 hours, and water was added to the reaction mixture. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 96.5 g of (4-isopropylphenyl)acetonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07563822B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-9df1e22e76ea4d78b29edcb781d8aa95 |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
