Tert-Butylamine → HCID 86760921, 화합물

반응식

C([C:4]1[CH:5]=[CH:6][C:7]([CH2:14][CH2:15][NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])=[C:8]([S:10](Cl)(=[O:12])=[O:11])[CH:9]=1)(C)C.[C:23]([NH2:27])([CH3:26])([CH3:25])[CH3:24].O1C[CH2:31][CH2:30][CH2:29]1>>[C:23]([NH:27][S:10]([C:8]1[CH:9]=[CH:4][C:5]([CH:30]([CH3:31])[CH3:29])=[CH:6][C:7]=1[CH2:14][CH2:15][NH:16][C:17](=[O:22])[C:18]([F:19])([F:20])[F:21])(=[O:11])=[O:12])([CH3:26])([CH3:25])[CH3:24]

참가 물질

반응물 3

HCID 6385Tert-Butylamine

HCID 8028Tetrahydrofuran

HCID 17856313HCID 17856313, 화합물

생성물 1

HCID 86760921HCID 86760921, 화합물

실험 절차

To a solution of 0.463 g of 5-isopropyl-2-[2-(2,2,2-trifluoroacetylamino)ethyl]benzenesulfonyl chloride in 30 mL of tetrahydrofuran was added 0.500 mL of tert-butylamine. The mixture was sealed and stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in 30 mL of water and 10 mL of 1 mol/L hydrochloric acid. The mixture was extracted with ethyl acetate, and the organic layer was washed with water, saturated aqueous sodium bicarbonate solution, and brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give 0.481 g of N-[2-(2-tert-butylsulfamoyl-5-isopropylphenyl)ethyl]-2,2,2-trifluoroacetamide.