Phenol → Butyl phenyl ether

HRID 2296262

반응식

HRID 2296262 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O-]CC.[Na+].Br[CH2:13][CH2:14][CH2:15][CH3:16]>C(O)C>[CH2:13]([O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 996PhenolHCID 8002Butyl bromideHCID 2723922Sodium ethoxide

생성물 1

HCID 14311Butyl phenyl ether

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Phenol (0.5 mole) was added to a solution of sodium ethoxide in ethanol (2 N; 250 ml) and 1-bromobutane (0.5 mole) was added dropwise while stirring. The mixture was heated under reflux for three hours and most of the solvent was then distilled off. Water was added to the residue and the organic layer was separated, washed twice with 10% aqueous NaOH, water, dilute H2SO4 and water, and was then dried over MgSO4. It was distilled in vacuo to give the title compound, b.p. 88°-91° C. at 14 mm Hg pressure. The identity and purity was confirmed by thin layer chromatography (TLC) and NMR and IR spectroscopy.

후처리

  1. additionwas added dropwise
  2. temperatureThe mixture was heated
  3. temperatureunder reflux for three hours and most of the solvent
  4. distillationwas then distilled off
  5. additionWater was added to the residue
  6. customthe organic layer was separated
  7. washwashed twice with 10% aqueous NaOH, water, dilute H2SO4 and water
  8. dry with materialwas then dried over MgSO4
  9. distillationIt was distilled in vacuo

출처 및 근거

ORD 기록
ord-87537f9e6c1d4b2685772a48db40c3c3
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04428889

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