Ethanol → HCID 178479647, 화합물

반응식

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].[ClH:7].C(=N)(OCC)[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)O.[CH2:21]([OH:23])C>>[ClH:7].[OH:23][C:21]1[N:1]([CH2:9][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][N:6]=1

참가 물질

반응물 3

HCID 702Ethanol

HCID 1045Putrescine

HCID 12387918Ethyl 1-hydroxy-1-phenylmethanecarboximidate hydrochloride

생성물 1

HCID 178479647HCID 178479647, 화합물수율 34%

실험 절차

To 200 ml of absolute ethanol was added 1,4-diaminobutane at 0° C. with continuous stirring. To this solution waas added an equal molar amount of ethyl mandelimidate hydrochloride. After stirring at 0°-5° C. for two hours, the suspension was heated under reflux 12 hours then cooled and concentrated to remove any traces of NH3. The concentrated solution was acidified by dropwise addition of ethanolic HCl into the suspension which was then concentrated to dryness and the residue recrystallized several times from CH3CN/ether to yield 14.5 g (34%) of product: mp 179°-181° C. Structure was confirmed by IR and NMR.