Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2296463생성일: 2026년 10월 25일
Dimethylformamide → Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate
https://huagongshe.com/reaction/2296463
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| 반응물 | 4-Amino-6-(2-ethylbutyramido)quinazoline | HCID 13060462 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060503 | 56.1% |
반응 단계
A mixture of 4-amino-6-(2-ethylbutyramido)quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04429126 |
|---|
| 출처 데이터셋 | uspto-grants-1984_01 |
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| ORD ID | ord-cea7b45ff99f4210a996cffd7049cf85 |
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| 출처 메모 | uspto-grants-1984_01 |
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