Chloroacetonitrile → HCID 18387782, 화합물

HRID 2296665노트

반응식

HRID 2296665 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl[CH2:14][C:15]#[N:16].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[C:15]([CH2:14][O:12][C:9]1[CH:10]=[CH:11][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:7][CH:8]=1)#[N:16]

참가 물질

6

반응물 3

HCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 35641974-Thiophen-2-ylphenol

생성물 1

HCID 18387782HCID 18387782, 화합물수율 91.3%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-(2-thienyl)phenol (1.30 g), chloroacetonitrile (668 mg) and potassium carbonate (1.53 g) in DMF (7 ml) was stirred for 5 hours at ambient temperature. The mixture was diluted with H2O and the separated solid was recovered to give 1.45 g of 2-(4-cyanomethoxyphenyl)thiophene.

후처리

  1. customthe separated solid was recovered

출처 및 근거

ORD 기록
ord-b99eff66cdf2434392737e7e5f77e7e5
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06489324B2

반응 노트

불러오는 중…