2-Fluorobenzoyl chloride → [4-(2-Fluorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

HRID 2297255노트

반응식

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=O.ClC1C=C(Cl)C=CC=1C1[C:24]([C:25]2[NH:26][CH:27]=[CH:28][N:29]=2)=[CH:23][N:22]=[C:21]([NH:30][CH2:31][CH2:32][NH:33][C:34]2[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][N:35]=2)[N:20]=1>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]1[C:24]([C:25]2[NH:29][CH:28]=[CH:27][N:26]=2)=[CH:23][N:22]=[C:21]([NH:30][CH2:31][CH2:32][NH:33][C:34]2[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][N:35]=2)[N:20]=1

참가 물질

반응물 2

HCID 98082-Fluorobenzoyl chloride

HCID 9847557Chir-98023

생성물 1

HCID 22142676[4-(2-Fluorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

실험 절차

[4-(2-fluorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine was prepared from 2-fluorbenzoyl chloride using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

출처 및 근거

ORD 기록: ord-c9bae50afda04ed1a205c6fd214b6b33
출처 데이터셋: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06489344B1

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