Benzyl Isothiocyanate → 4-Benzyl-1-(thiophene-2-carbonyl)thiosemicarbazide

HRID 229757

반응식

HRID 229757 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][NH2:9])=[O:7].[CH2:10]([N:17]=[C:18]=[S:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[CH2:10]([NH:17][C:18]([NH:9][NH:8][C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:7])=[S:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 2346Benzyl IsothiocyanateHCID 73098Thiophene-2-carbohydrazide

생성물 1

HCID 52606884-Benzyl-1-(thiophene-2-carbonyl)thiosemicarbazide수율 89.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a hot solution of 2-thiophencarboxylic acid hydrazide (5.0 g, 35 mmol) in acetonitrile (80 mL) was added neat benzyl isothiocyanate (4.7 mL, 35 mmol) via syringe. When the solvent started to boil, the reaction vessel was removed from the heat source and allowed to cool to room temperature. The resulting crystals were collected by vacuum filtration, washed with diethyl ether and air-dried to yield N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide (9.11 g; 89%; (M+H)+−292.2).

후처리

  1. customthe reaction vessel was removed from the heat source
  2. filtrationThe resulting crystals were collected by vacuum filtration
  3. washwashed with diethyl ether
  4. customair-dried

출처 및 근거

ORD 기록
ord-af782016dd43493eba98f290432a7005
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07563905B2

연결된 노트

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