Dimethylformamide → HCID 18383995, 화합물

HRID 2297731노트

반응식

[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6].[C:12](=[O:15])([O-])[O-].[K+].[K+].[CH3:18][O:19][CH2:20]Cl.[CH3:22]N(C)C=O>>[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:11][CH2:22][O:15][CH3:12])[C:9]=1[O:10][CH2:18][O:19][CH3:20])[CH:5]=[O:6]

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 7864Chloromethyl Methyl Ether

HCID 11430Potassium Carbonate

HCID 836513,4,5-Trihydroxybenzaldehyde

생성물 1

HCID 18383995HCID 18383995, 화합물수율 17%

실험 절차

3,4,5-Trihydroxybenzaldehyde (628 mg, 3.6 mmol) was dissolved in dimethylformamide (30 mL), and potassium carbonate (2.0 g, 14 mmol) was added thereto, followed by stirring at room temperature for 30 minutes. Next, chloromethyl methyl ether (0.96 mL, 13 mmol) was added thereto, followed by stirring at room temperature for 2 hours. After the conventional post-treatment, the residue was purified by preparative thin layer chromatography (developed with chloroform/methanol=98/2) to give 3-hydroxy-4,5-bis(methoxymethoxy)benzaldehyde (140 mg, yield 17%).

후처리

stirringby stirring at room temperature for 2 hours
customAfter the conventional post-treatment, the residue was purified by preparative thin layer chromatography (developed with chloroform/methanol=98/2)

출처 및 근거

ORD 기록: ord-21707e02c84548ddb23ab068bf97fe96
출처 데이터셋: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06492392B1

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