Ethyl glycylglycinate → (2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzylamino}-acetylamino)-acetic acid ethyl ester

HRID 2297784

반응식

HRID 2297784 반응식
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][NH:6][C:7](=[O:10])[CH2:8][NH2:9])[CH3:2].[NH:12]1[C:20]2[C:15](=[CH:16][C:17]([NH:21][C:22]3[C:23]4[S:30][C:29]([C:31]5[CH:38]=[CH:37][C:34]([CH:35]=O)=[CH:33][CH:32]=5)=[CH:28][C:24]=4[N:25]=[CH:26][N:27]=3)=[CH:18][CH:19]=2)[CH:14]=[CH:13]1>>[CH2:1]([O:3][C:4](=[O:11])[CH2:5][NH:6][C:7](=[O:10])[CH2:8][NH:9][CH2:35][C:34]1[CH:33]=[CH:32][C:31]([C:29]2[S:30][C:23]3[C:22]([NH:21][C:17]4[CH:16]=[C:15]5[C:20](=[CH:19][CH:18]=4)[NH:12][CH:13]=[CH:14]5)=[N:27][CH:26]=[N:25][C:24]=3[CH:28]=2)=[CH:38][CH:37]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 124706Ethyl glycylglycinateHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

생성물 1

HCID 53837241(2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzylamino}-acetylamino)-acetic acid ethyl ester

실험 절차

The title compound was prepared from (2-amino-acetylamino)-acetic acid ethyl ester and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. M.P. 98-115° C.; LC-MS: 515 (MH+); HPLC RT: 3.88 minutes.

출처 및 근거

ORD 기록
ord-e0e6cb8f164442698f9b11b7854bb4c0
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06492383B1

연결된 노트

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