HCID 2757862, 화합물 → HCID 18382865, 화합물

반응식

[C:1]1([CH3:15])[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH:2]=1.Cl[C:17]1[C:18]2[S:25][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:23][C:19]=2[N:20]=[CH:21][N:22]=1>>[C:26]1([C:24]2[S:25][C:18]3[C:17]([NH:14][C:11]4[CH:12]=[CH:13][C:8]([NH:7][C:3]5[CH:2]=[C:1]([CH3:15])[CH:6]=[CH:5][CH:4]=5)=[CH:9][CH:10]=4)=[N:22][CH:21]=[N:20][C:19]=3[CH:23]=2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

반응물 2

HCID 2757862HCID 2757862, 화합물

HCID 4764078HCID 4764078, 화합물

생성물 1

HCID 18382865HCID 18382865, 화합물수율 21%

실험 절차

Utilizing a procedure analogous to that described in Example 61, the title compound was prepared in 21% yield from N-m-Tolyl-benzene-1,4-diamine (230 mg, 1.16 mmol) and 4-chloro-6-phenyl-thieno[3,2-d]pyrimidine 250 mg, 1.16 mmol). RP18-HPLC RT: 7.432 minutes; APl MS: 409.1 (M+1); MP: 170-171° C.

출처 및 근거

ORD 기록: ord-11b8dc0979e2434dab88ba82aaf70cb2
출처 데이터셋: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06492383B1

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