Methyl 5-(3-((tert-butoxycarbonyl)amino)prop-1-yn-1-yl)furan-2-carboxylate → 5-(3-Tert-butoxycarbonylaminopropyl)-furan-2-carboxylic acid methyl ester

HRID 2298228노트

반응식

HRID 2298228 반응식
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([C:10]#[C:11][CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[CH:8][CH:9]=1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[CH:8][CH:9]=1)=[O:4]

참가 물질

4

반응물 1

HCID 53793873Methyl 5-(3-((tert-butoxycarbonyl)amino)prop-1-yn-1-yl)furan-2-carboxylate

생성물 1

HCID 536486615-(3-Tert-butoxycarbonylaminopropyl)-furan-2-carboxylic acid methyl ester수율 24.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 5-(3-tert-butoxycarbonylamino-prop-1-ynyl)-furan-2-carboxylic Acid methyl ester (1.69 g) in MeOH (50 mL) was added 10% palladium on carbon (850 mg) and the mixture was hydrogenated on a Parr shaker at 50 psi for 18 h. The catalyst was removed via filtration through Celite and the volatiles were concentrated in vacuo. Flash chromatography (hexanes:EtOAc 4:1) provided 5-(3-tert-butoxycarbonylaminopropyl)-furan-2-carboxylic Acid methyl ester (422 mg, MS 284 M+) followed by 5-(3-tert-butoxycarbonylamino-propyl)-tetrahydrofuran-2-carboxylic Acid methyl ester (903 mg).

후처리

  1. customThe catalyst was removed via filtration through Celite
  2. concentrationthe volatiles were concentrated in vacuo

출처 및 근거

ORD 기록
ord-6cfff630f65c4f74837b057a3ccdd9d9
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06492412B2

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