Acetic Acid → HCID 11287643, 화합물

HRID 2298436노트

반응식

HRID 2298436 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])=[CH:3][CH:2]=1.C(O)(=O)C>CO.[Pd]>[NH:1]1[CH2:2][CH2:3][CH:4]([CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:6]1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 120570091,3-Dimethyl 2-(4-pyridinylmethylene)propanedioate

생성물 1

HCID 11287643HCID 11287643, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of dimethyl (4-pyridylmethylene)malonate [XXVIIIa] (925 g) in methanol (9 L) was hydrogenated in the presence of glacial acetic acid (360 mL) and 10% palladium on activated carbon catalyst (92.5 g) at 60° C. and 200 psi. The catalyst was filtered off and the resulting solution of the title compound in the form of acetic acid salt was used directly in the next step.

후처리

  1. filtrationThe catalyst was filtered off

출처 및 근거

ORD 기록
ord-26afa65d638d4deba309efa9ae0b00e1
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06492522B1

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