Acetate → HCID 15389278, 화합물

HRID 2298438노트

반응식

HRID 2298438 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1.CC([O-])=O>C(O)C.[Pd]>[NH:1]1[CH2:2][CH2:3][CH:4]([CH:7]=[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:5][CH2:6]1

참가 물질

5

반응물 2

HCID 175AcetateHCID 5307014HCID 5307014, 화합물

생성물 1

HCID 15389278HCID 15389278, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of diethyl (4-pyridylmethylene)malonate [XXVIIIb] (97.6 g) in absolute ethanol (1 L) was hydrogenated in the presence of acetic acid glacial (35.5 g) and 10% Palladium on activated carbon catalyst (9.7 g) at 60° C. and 200 psi for 20 hours. The catalyst was filtered off and the resulting solution of the title compound in the form of acetic acid salt was used directly in the next step.

후처리

  1. filtrationThe catalyst was filtered off

출처 및 근거

ORD 기록
ord-44b5694bb4a24c35ba698b3e00e2f5e6
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06492522B1

반응 노트

불러오는 중…