Morpholine → 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole

HRID 2298812노트

반응식

HRID 2298812 반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.C(=O)([O-])O.[Na+]>>[N:14]1([C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=3[N:3]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

참가 물질

4

반응물 3

HCID 8083MorpholineHCID 516892Sodium BicarbonateHCID 14765451HCID 14765451, 화합물

생성물 1

HCID 183786202-(morpholin-4-yl)-4-nitro-1H-benzimidazole

반응 조건

온도
50 °C

실험 절차

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and morpholine (1 ml) was stirred at 50° C. for 8 hours. The reaction mixture was poured into saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The organic layer was washed with brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo. The residue was washed with isopropyl ether and collected by vacuum filtration to give 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole (288 mg).

후처리

  1. extractionextracted with chloroform
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated in vacuo
  5. washThe residue was washed with isopropyl ether
  6. filtrationcollected by vacuum filtration

출처 및 근거

ORD 기록
ord-1974a1f013ee4591b081c81e72c586ad
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06495542B1

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