참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ibandronate | HCID 60852 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ibandronate Sodium Anhydrous | HCID 23670359 | 93.6% |
반응 단계
A solution of amorphous ibandronic acid (2.7 g) in water (25 ml) and sodium hydroxide (0.34 g, solid) was stirred at 70° C. The solution was poured into cold IPA (500 ml). The resulting precipitate was stirred at 0° C. for 16 hours. The precipitate was isolated by vacuum filtration and dried in a vacuum oven at 50° C. for 24 hours to obtain 2.7 g of ibandronate sodium crystal form K3. Form K3 can exhibit a weight loss of about 7% to about 8% in TGA.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07563918B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-df61eb585e5741eda33bb880dec71106 |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
