Dimethylformamide → 2-Bromo-1-(3-methylbut-2-enylthio)benzene

HRID 22991

반응식

HRID 22991 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].CN(C=O)C.C(=O)([O-])[O-].[K+].[K+].Br[CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24]>O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 700922-Butene, 1-bromo-3-methyl-HCID 805982-Bromobenzenethiol

생성물 1

HCID 106348752-Bromo-1-(3-methylbut-2-enylthio)benzene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

19.30 g (102.0 mmol) of 2-bromothiophenol, 160 ml of DMF and 15.50 g (112.0 mmol) of potassium carbonate are introduced into a three-necked flask. 13 ml (112.0 mmol) of 1-bromo-3-methyl-2-butene are added dropwise and the reaction mixture is stirred at room temperature for two hours. It is poured into water and extracted with ethyl acetate and the organic phase is separated by settling, washed with water, dried over magnesium sulphate and evaporated. 26.00 g (99%) of the expected compound are collected in the form of an orangey oil.

후처리

  1. extractionextracted with ethyl acetate
  2. customthe organic phase is separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. custom26.00 g (99%) of the expected compound are collected in the form of an orangey oil

출처 및 근거

ORD 기록
ord-cc4dd4a925134e97806965f18a207e98
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849658B2

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