Cornforth reagent → 5,6-dihydro-6-methoxy-2H-pyran-3(4H)-one

HRID 2299109노트

반응식

HRID 2299109 반응식
C1C=C[NH+]=CC=1.C1C=C[NH+]=CC=1.[O-][Cr](O[Cr]([O-])(=O)=O)(=O)=O.[CH3:22][O:23][CH:24]1[O:29][CH2:28][CH:27]([OH:30])[CH2:26][CH2:25]1>C(Cl)Cl>[CH3:22][O:23][CH:24]1[O:29][CH2:28][C:27](=[O:30])[CH2:26][CH2:25]1

참가 물질

4

반응물 2

HCID 2724130Cornforth reagentHCID 122006502H-Pyran-3-ol, tetrahydro-6-methoxy-

생성물 1

HCID 1282735,6-dihydro-6-methoxy-2H-pyran-3(4H)-one수율 25.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

PDC (6.0 g, 28 mmol) was added to a solution of 6-methoxytetrahydro-2H-pyran-3-ol (2.0 g, 15 mmol) from step (394a) in methylene chloride (50 ml) at room temperature. The reaction was stirred overnight, filtered through silica gel and concentrated to give an oil. The product was distilled at 35° C. at 1000 mtorr pressure to give the 6-methoxydihydro-2H-pyran-3-(4H)-one (0.5 g, 25%) as an oil.

후처리

  1. filtrationfiltered through silica gel
  2. concentrationconcentrated
  3. customto give an oil
  4. distillationThe product was distilled at 35° C. at 1000 mtorr pressure

출처 및 근거

ORD 기록
ord-f135f214a31248988c78dccee744c0c9
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06495565B2

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