Bromine → 2-Cyclopropyl-4-bromo-5-aminobenzimidazole
반응식
[CH:1]1([C:4]2[NH:5][C:6]3[CH:12]=[C:11]([NH2:13])[CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1.[Br:14]Br>CC(O)=O>[CH:1]1([C:4]2[NH:5][C:6]3[C:12]([Br:14])=[C:11]([NH2:13])[CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of 0.87 g (4.9 mmol) of 2-cyclopropyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.10 ml (1.9 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (5% MeOH/EtOAC) to yield 0.42 g (1.8 mmol, >95%) of the desired product.
후처리
- customresulting
- customreaction mixture
- concentrationThe reaction mixture was concentrated in vacuo
- custompurified on silica gel column chromatography (5% MeOH/EtOAC)
출처 및 근거
- ORD 기록
- ord-7b644f429e1b453e8d8a2b0f46f34441
- 출처 데이터셋
- uspto-grants-2002_12
- 특허 번호
- US06495583B1
반응 노트
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