Dimethyl Pentadecanedioate → Methyl 15-Hydroxypentadecanoate

HRID 2299573

반응식

HRID 2299573 반응식
[C:1](OC)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16].[H][H]>>[OH:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]

참가 물질

3

반응물 2

HCID 11415366Dimethyl PentadecanedioateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 3496889Methyl 15-Hydroxypentadecanoate수율 61%

실험 절차

150 g (499 mmol) of dimethyl 1,15-pentadecandioate and 12 g (8.0% by weight per the diester) of the catalyst prepared in Preparative Example 1 were added to an autoclave and subjected to hydrogenation reaction at the hydrogen pressure of 20.0 Mpa at 250° C. After 8 hours, the degree of the conversion was 63% and the selectivity was 87%. The reaction was further continued, and after 10 hours, methyl 15-hydroxypentadecanoate was obtained in 61% yield. The results are shown in Table 2.

후처리

  1. additionwere added to an autoclave
  2. waitafter 10 hours

출처 및 근거

ORD 기록
ord-0eebe7be8f0446008ebcfbaa888f6a73
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06495706B2

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