Bromine → Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate

HRID 2300669노트

반응식

HRID 2300669 반응식
[Br:1]Br.[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:9])=[CH:6][CH:5]=1>ClCCl>[Br:1][CH:10]([C:8](=[O:9])[C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:21][CH:20]=1)[CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

참가 물질

4

반응물 2

HCID 24408BromineHCID 11065929Ethyl 7-(4-chlorophenyl)-7-oxoheptanoate

생성물 1

HCID 11810554Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate수율 99.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Bromine(21.1 g) was added dropwise to a dichloromethane solution (200 ml) of ethyl 6-(4-chlorobenzoyl)hexanoate (37.3 g) at room temperature. After stirring for 30 minutes, the reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn. The dichloromethane layer was dried(MgSO4). The solvent was evaporated to give ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate(47.6 g, quant.) as an oily substance.

후처리

  1. washthe reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn
  2. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-36616594bbb44475a902eccb52f28337
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06498179B1

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