2-Chlorobenzylamine → HCID 18375656, 화합물

반응식

CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH2:24]>>[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH:24][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

참가 물질

반응물 2

HCID 666482-Chlorobenzylamine

HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

생성물 1

HCID 18375656HCID 18375656, 화합물

실험 절차

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 2-chlorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (EI): m/e 335.0 (M+). 1H NMR (500 MHz, CDCl3): δ partial 8.60 (s, 1H); 8.43 (d, J=3.9 Hz, 1H); 8.02 (br s, 1H); 7.85 (m, 1H); 7.37 (m, 2H); 6.85 (d, J=5.5 Hz, 1H); 5.93 (br s, 1H); 4.85 (d, J=6.2 Hz, 2H).

출처 및 근거

ORD 기록: ord-b61e90eaf68f4ac8850f5169b6cdaf7d
출처 데이터셋: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06498165B1

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