홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2-[(S)-1-phenylethylamino]-4-[5-aminobenzimidazol-1-yl]pyrimidine → 2-[(S)-1-phenylethylamino]-4-[5-(pyrimidin-4-yl)aminobenzimidazol-1-yl]pyrimidine

HRID 2300894
노트
인쇄 미리보기

반응식

HRID 2300894 반응식
[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([NH2:25])=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[CH:12][N:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([NH:25][C:12]5[CH:13]=[CH:14][N:15]=[CH:10][N:11]=5)=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[CH:12][N:11]=2)[CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 98839772-[(S)-1-phenylethylamino]-4-[5-aminobenzimidazol-1-yl]pyrimidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 99093772-[(S)-1-phenylethylamino]-4-[5-(pyrimidin-4-yl)aminobenzimidazol-1-yl]pyrimidine수율 63.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-[(S)-1-phenylethylamino]-4-[5-aminobenzimidazol-1-yl]pyrimidine (14.0 mg) was dissolved in 2 mL MeOH, 10%Pd/C (20.3 mg) added, the system fitted with a balloon of hydrogen, purging the system twice and leaving the reaction stirring at room temperature for 23 h. The mixture was then filtered through Celite®, washing thoroughly with methanol, and the solvent removed in vacuo. The residue was purified on silica gel (2-5%(2M NH3 in MeOH)/CH2Cl2) to yield 5.5 mg of the title compound. Mass spectrum (ESI) 409.4 (M+1).

후처리

  1. custompurging the system twice
  2. customleaving the reaction
  3. filtrationThe mixture was then filtered through Celite®
  4. washwashing thoroughly with methanol
  5. customthe solvent removed in vacuo
  6. customThe residue was purified on silica gel (2-5%(2M NH3 in MeOH)/CH2Cl2)

출처 및 근거

ORD 기록
ord-ec468ceaac1e48b9923c33120aaac479
출처 데이터셋
uspto-grants-2002_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06498165B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트