Sodium Acetate → 7-Methoxyflavone

HRID 2301344

반응식

HRID 2301344 반응식
O[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:20])[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:9][O:8][C:6]1[CH:5]=[C:4]2[C:3]([C:10](=[O:20])[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13]2)=[CH:2][CH:7]=1

참가 물질

4

반응물 2

HCID 517045Sodium AcetateHCID 114145481-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione

생성물 1

HCID 4662687-Methoxyflavone수율 70%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

240 mg (0.89 mmol) of 1-(2-hydroxy-4-methoxy-phenyl)-3-phenyl-propan-1,3-dione was dissolved in acetic acid, and 0.73 g (8.9 mmol) of sodium acetate was added thereto. The mixture was refluxed overnight. Acetic acid was removed by distillation under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=5/1, v/v) to give the title compound in a yield of 70%.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. customAcetic acid was removed by distillation under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (eluent

출처 및 근거

ORD 기록
ord-59fd021b16774d859d824e784f15c118
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06500846B1

연결된 노트

불러오는 중…