Boron tribromide → HCID 18372862, 화합물

HRID 2301354노트

반응식

HRID 2301354 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:12]4[C:17]([C:18](=[O:21])[C:19]=3[OH:20])=[C:16]([O:22][CH3:23])[CH:15]=[CH:14][CH:13]=4)=[CH:9][C:4]=2[O:3]C1.B(Br)(Br)Br>>[OH:3][C:4]1[CH:9]=[C:8]([C:10]2[O:11][C:12]3[C:17]([C:18](=[O:21])[C:19]=2[OH:20])=[C:16]([O:22][CH3:23])[CH:15]=[CH:14][CH:13]=3)[CH:7]=[CH:6][C:5]=1[OH:1]

참가 물질

3

반응물 2

HCID 25134Boron tribromideHCID 98397442-(Benzo[1,3]dioxol-5-yl)-3-hydroxy-5-methoxy-chromen-4-one

생성물 1

HCID 18372862HCID 18372862, 화합물수율 40,315,552%

실험 절차

The reaction was conducted according to the same procedure as Example 57 except that 60 mg (190 pmol) of the compound obtained in Example 4 instead of the compound obtained in Example 12 and 1.5 molar equivalents of boron tribromide (BBr3) were used. Then the resulting product was separated by preparative TLC to give 23 mg of the title compound in a yield of 40%.

후처리

  1. customThen the resulting product was separated by preparative TLC

출처 및 근거

ORD 기록
ord-5c2757a6cef243a382d8ab72d0febe8f
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06500846B1

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