Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Difluorophenylacetic acid → (S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 반응물 | (S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride | HCID 69741166 | — |
| 생성물 | (S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline | HCID 69743302 | — |
반응 단계
Following General Procedure A above and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride (Example G), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.2 in 1:1 EtOAc/hexanes) and the product was purified by silica gel chromatography using 1:1 EtOAc/hexanes as the eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849650B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-4b5f11cfbb094dedbb3d02741f1c7ebc |
| 출처 메모 | uspto-grants-2005_02 |