Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Difluorophenylacetic acid → (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 반응물 | (s)-2-(1-Aminoethyl)-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723742 | — |
| 용매 | Chloroform methanol | HCID 21584188 | — |
| 생성물 | (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723741 | — |
반응 단계
Following General Procedure A and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-5(R,S)-ethoxycarbonyl-2-oxazoline (Example F), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.3 in 5% MeOH/CHCl3) and the product was purified by silica gel chromatography using 5% MeOH/CHCl3 as the eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849650B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-c299ca4730364ed6b87f71d07b1e409a |
| 출처 메모 | uspto-grants-2005_02 |