Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-{6-Azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 2-{6-Chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol | HCID 11118967 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-{6-Azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol | HCID 11807790 | 87.5% |
반응 단계
A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728706 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-c78f869bf2a74b75ba8846f932a65794 |
| 출처 메모 | uspto-grants-1998_03 |