(+-)-Cyclohexylphenylglycolic acid → N-Desethyloxybutynin

반응식

[CH:1]1([C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([OH:11])[C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:18]([NH:20][CH2:21][C:22]#[C:23][CH2:24]Cl)[CH3:19]>>[CH:12]1([C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)([OH:11])[C:8]([O:10][CH2:24][C:23]#[C:22][CH2:21][NH:20][CH2:18][CH3:19])=[O:9])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

반응물 2

HCID 97700(+-)-Cyclohexylphenylglycolic acid

HCID 184595064-Ethylamino-2-butynyl chloride

생성물 1

HCID 133577N-Desethyloxybutynin

실험 절차

by standard esterification technique, reacting cyclohexylphenyl glycolic acid with 4-ethylamino-2-butynyl chloride to produce 4-ethylamino-2-butynyl cyclohexylphenyl-glycolate (DEO).

출처 및 근거

ORD 기록: ord-89277cc64fd14c4e9fd29ee6f4154367
출처 데이터셋: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06432446B1

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