Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 4-Chloro-2-(isoxazol-5-yl)-6-methyl-thieno-[2,3-d]-pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| 반응물 | 1,2-Oxazole-5-carbonitrile | HCID 11228764 | — |
| 생성물 | 4-Chloro-2-(isoxazol-5-yl)-6-methyl-thieno-[2,3-d]-pyrimidine | HCID 18460250 | — |
반응 단계
With the procedure of Example 477, the reaction of 5-cyanoisoxazole and 2-amino-5-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(isoxazol-5-yl)-6-methyl-thieno-[2,3-d]-pyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06432950B1 |
| 출처 데이터셋 | uspto-grants-2002_08 |
| ORD ID | ord-24c94b67158e478598b818585d43f72e |
| 출처 메모 | uspto-grants-2002_08 |