Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Iodoaniline → N-(4-iodophenyl)-4,6-dimethoxypyrimidin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Iodoaniline | HCID 10893 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-4,6-dimethoxypyrimidine | HCID 5152323 | — |
| 생성물 | N-(4-iodophenyl)-4,6-dimethoxypyrimidin-2-amine | HCID 66911973 | 39.3% |
반응 단계
In the same manner as in Reference Example 24-(1), 4-iodoaniline (220 mg) and 2-chloro-4,6-dimethoxypyrimidine (200 mg) were reacted in the presence of sodium hydride to obtain N-(4-iodophenyl)-4,6-dimethoxypyrimidin-2-amine (141 mg). (2) In the same manner as in Reference Example 24-(2), sodium hydride (16 mg), N-(4-iodophenyl)-4,6-dimethoxypyrimidin-2-amine (140 mg) and methyl iodide (0.024 ml) were reacted to obtain N-(4-iodophenyl)-4,6-dimethoxy-N-methylpyrimidin-2-amine (118 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07566724B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-0244de1553dc4b859bf8a35a37af598d |
| 출처 메모 | uspto-grants-2009_07 |