HCID 18461418, 화합물 → 5-{4-[6-(3,5-Di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

HRID 2303802노트

반응식

HRID 2303802 반응식
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:50]=[CH:49][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[C:29]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:28]([OH:35])=[C:27]([C:36]([CH3:39])([CH3:38])[CH3:37])[CH:26]=4)=[CH:20][C:19]=3[N:40]([CH3:48])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:51].O1CCOCC1>>[ClH:51].[C:36]([C:27]1[CH:26]=[C:25]([CH:30]=[C:29]([C:31]([CH3:32])([CH3:34])[CH3:33])[C:28]=1[OH:35])[O:24][C:21]1[CH:22]=[CH:23][C:18]2[N:17]=[C:15]([CH2:14][O:13][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH:4]4[S:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])=[CH:50][CH:49]=3)[N:40]([CH3:48])[C:19]=2[CH:20]=1)([CH3:39])([CH3:38])[CH3:37]

참가 물질

3

반응물 2

HCID 18461418HCID 18461418, 화합물HCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 867584465-{4-[6-(3,5-Di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

실험 절차

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3,5-di-t-butyl-4-hydroxyphenoxy)phenyl}-N-methylcarbamate (0.72 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at room temperature for 17 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (0.41 g).

후처리

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-175f68421dd7418787cc934b4fdeeeda
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06432993B1

반응 노트

불러오는 중…